Is Milk thistle toxic?

Stachyose food additives

Is Milk thistle toxic?

20/12/2021 blog 0

Milk thistle itself has a certain ventilation ability, can be used as a laxative, so people with gastrointestinal problems should be careful to use, in addition to plant allergy people should stay away from milk thistle, to ensure that when it will produce an allergic reaction.  

Milk thistle, because its stem and leaf break will flow out of the white tissue fluid like milk, so it has another name milk tree.  

In A.D. 77, Pilny the Elder, a Roman, discovered the extraordinary effectiveness of milk thistle in treating liver diseases, and as late as the 15th century, medieval doctors routinely thought of milk thistle first when they encountered patients with liver problems. By the 1960s,  Silybin, silymarin and silymarin were extracted from silymarin as extracts, capsules, and tablets, which have protective effects on the liver.  

In addition to protecting the liver and treating liver diseases, silythistle can also protect the kidneys, lungs, central nervous system and other tissues and organs.  However, compared with foreign countries, domestic reports on the nutritional composition and specific principles of silythistle are less, so there are not many people who know this herb, even if it is mentioned occasionally, it is only a brief talk about the efficacy and effect.  

However, it is known to all that the drug is toxic. So far, there have been few reports about the toxicity and side effects of milk thistle in detail. This article mainly discusses the toxicity and side effects of milk thistle.  

The first experiment — acute toxicity of silibinin  

At present, we can see many extracts of silybin, capsules and pills of silybin in pharmacies, such as capsules of Silybin produced by Tianjin Tiansli Shengte Pharmaceutical Co., LTD, and tablets of silybin megalumine produced by Hunan Qianjin Xiexian Pharmaceutical Co., LTD…  There are many similar drugs, most of which are used to treat liver diseases.  

Researchers have studied the pills and capsules in hopes of improving the country’s understanding of the toxicity of silythistle.  

The effects of silythistle capsules and tablets on mice were determined by gavage, detection of mutagenicity caused by pollutants, observation of sperm malformation and micronucleus of mouse bone marrow cells.  

The mice showed no symptoms of poisoning and no deaths 14 days later.  Even at the maximum tolerated dose, the mice were not poisoned.  

In Ames test, the results were negative and could be repeated.  

The micronucleus rate and PCE/NCE of mouse bone marrow cells were not statistically significant in the different doses of silythil capsules compared with the solvent control group. Even at high doses, the micronucleus rate of mouse bone marrow cells was not increased.  

Finally the sperm deformity in mice experiment, the result and similar mice bone marrow cell micronucleus test, sperm deformity rate and solvent control group the difference was not statistically significant, under the same conditions, cyclophosphamide sperm deformity rate of positive control group and solvent control group and control group with statistical significance of each dose of milk thistle capsules  This suggests that the silythistle capsules, at least, had no abnormal effect on the mice’s sperm.  

Overall, milk thistle capsules and no side effects, according to the classification standard, acute toxicity of milk thistle capsules can be to non-toxic material, in addition, due to the milk thistle capsules in mice bone marrow micro nuclear test and mouse sperm aberration test results are negative, so you can prove that milk thistle capsules had no mutagenic effects for somatic cell and germ cell.  

The second experiment studied acute toxicity, genotoxicity and subchronic toxicity of silythistle extracts  

This experiment is to milk thistle capsules of acute toxicity and genetic toxicity study of hunan province center for disease control and prevention researcher Huang Huang and zhang yingying and others also do the similar experiments of milk thistle extract of acute toxicity, genetic toxicity and chronic toxicity to do the research, the experimental results similar to the above, but much more detail,  Additional findings on subchronic toxicity.  

On the testing experiment, the chronic toxicity from milk thistle extract ninety days under the influence of feeding the mice did not gain weight, feeding rate, food utilization rate of abnormal, blood and blood biochemical indicators all normal, internal organs and the ratio of weight compared with control group, no statistical significance, solve the plane body in mice found no obvious anomalies.  

Simply put, silybin also does not have subchronic toxicity!  

The third experiment was to study the acute toxicity of silythistle meal in mice  

Although the first two studies have proved that silythistle is non-toxic, it does not mean that everyone can rest easy. After all, the previous two studies have covered three comprehensive areas, but they all used the extract of silythistle!  

You know, silybin isn’t the only thing in silybin, but what about other things?  Will it cause damage to humans or other creatures?  

Milk thistle meal used as fodder  

Researchers have studied this in order to find out whether the silymarin (silybin and other substances are silymarin) is still toxic from the fruit and seeds of silymarin in China.  The researchers specifically tested the milk thistle meal for acute toxicity.  

The experiment was mainly divided into four aspects: 1. The influence of gavage on the body weight of mice;  2. Analysis of acute toxicity test results;  3. Determination of organ index;  Iv. Determination of some biochemical indexes in serum.  The results showed that the mice gained weight after the instillation, but that was normal growth, not related to the milk thistle meal.  

In terms of acute toxicity, no mice died after 7 days, and no symptoms of poisoning were observed after dissection.  In terms of organs, according to the data, there was no hyperemia, edema, hyperplasia, hypertrophy, atrophy, degeneration and other changes, indicating that silythistle meal had no effect on the organs of mice.  

As for the determination of some biochemical indexes in serum, no significant difference was found between the serum total cholesterol and serum alanine transaminase, indicating that silythistle meal had no effect on the serum indexes of mice.  

So milk thistle meal is not toxic!  

In general, milk thistles are not toxic and are safe to eat.