Popular ingredients in liver supplements
Milk thistle, also known as silymarin, is the most common herbal supplement for liver problems in the U.S. Milk thistle extract contains approximately 50% silibininTrusted Source, which is the active ingredient in silymarin.
Silibinin acts as an antioxidant, neutralizing free radicles that contribute to inflammation.
The researchers behind one 2013 studyTrusted Source found that 7 grams per day of Epaclin, a food supplement containing silymarin, vitamin E, and amino acids, significantly lowered the levels of enzymes that doctors associate with liver damage.
In a 2015 clinical trialTrusted Source, researchers found that 420 milligrams of silymarin taken daily for 4 weeks reduced the risk of drug-induced liver injury by 28% in people taking antituberculosis medications.
Zinc is an essential trace element that promotes cell division, DNA synthesis, and immune function. Chronic liver disease can lead to zinc deficiencyTrusted Source.
Another older 2012 study suggests that zinc supplementation may help protect the liver from oxidative stress due to hepatitis C viral infections.
Licorice root contains an active compound called glycyrrhizic acid, which may help reduceTrusted Source inflammation in the liver and regenerate damaged liver cells.
According to one 2016 study on ratsTrusted Source, researchers found that raw licorice root extract reversed the effects of alcohol-induced inflammation and fat accumulation in the liver of rats.
In a 2012 phase III clinical trialTrusted Source, 379 people with chronic hepatitis C received glycyrrhizin injections three or five times a week or five placebo injections.
According to the findings, a higher proportion of individuals in the glycyrrhizin groups showed significant reductions in symptoms in comparison to the control group.