FOOD RES INT: Stachyose improves the intestinal barrier function of sterile mice after human fecal transplantation and reduces intestinal inflammation

Stachyose food additives

FOOD RES INT: Stachyose improves the intestinal barrier function of sterile mice after human fecal transplantation and reduces intestinal inflammation

21/06/2021 blog 0

The colonization mode of tract microorganisms in young children directly affects the diversity of microorganisms, physiological development and the development of the immune system, which in turn has a long-term impact on the risk of disease. Bacteroides and Enterobacter are the dominant intestinal microbes in 3-month-old breastfed infants, while the distribution of intestinal microbes in 6-month-12-month-old infants is unstable. Infants and young children are susceptible to gut microbes. A variety of factors, especially dietary intake, probiotics and dietary supplements. In the later stages of childhood, the imbalance of intestinal microbes may lead to chronic inflammatory diseases.

As a functional oligosaccharide, stachyose can protect the intestinal flora, effectively reduce chronic inflammation, diarrhea and colitis, and previous studies have also found that stachyose can promote the proliferation of Bifidobacterium and Lactobacillus. However, few studies have reported the effect of stachyose on the intestinal microbiome of infants, and the potential regulation mechanism of stachyose is currently unclear.

In this study, researchers transplanted infant feces into sterile mice to explore the effect of stachyose on gut microbes and host intestinal barrier function. Researchers have found that stachyose can increase the relative abundance of A. muciniphila in human feces and improve the symbiosis of A. muciniphila, and A. muciniphila, as an intestinal bacterium, can reduce the level of lipopolysaccharide in mice with intestinal barrier function damage. , Promote bacterial translocation and improve intestinal barrier function and immune function. Stachyose can also increase the levels of short-chain fatty acids and immunoglobulin A; reduce the levels of lipopolysaccharide, IL-1, IL-17 and TNF-α by down-regulating the expression of NF-κB; increase tight junction proteins (occludin and ZO- 1) and the expression of goblet cells. The intake of stachyose can promote the proliferation of beneficial bacteria in sterile mice and improve their intestinal barrier function. This research provides a theoretical basis for the use of stachyose to improve human intestinal microbes and barrier function.